Cytopoint Owner Feed-Back

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*****************Please let us know:*******************

What is your dog's name ?
What breed is it ?
Is your dog a male or a female ? Neutered or Intact ?
How old is it ?
Where do you live (just the city) ?
Your initials if you wish ?
How long has your dog been receiving Cytopoint ?
How often does she/he require a Cytopoint Injection ?
Was it on Apoquel before that ? Is it still ?
If it had abnormal blood values on Apoquel, did they improve on Cytopoint ? If you stopped Apoquel, because of skin tumors, did they shrink ?
More infections, less infections or the same # on Cytopoint vs Apoquel ?
What improvements have you noticed in its skin ?
Any changes or side effects other than improvement in the pet's skin ?
Anything else you want other readers to know ?

8/6/17
Hello Dr. Hines,
I have a 9 year old GSD, Dunbar, who has been itchy his whole life and for the last several years he has lived in a hood, since it steadily has increased. He is on Royal Canin Ultamino since he also seem to be an IBD dog although he's never been scoped. I was hoping the diet would also help the itching but it did not have any effect at all. We used Apoquel briefly but it really didn't make more than a slight difference and I was worried about the potential side effects. I have used Omegas, baths, everything I could find that might help. (short of cortisone). He had the Cytopoint injection about 2 weeks ago, and although it took him a full 48 hours to start seeing a difference, he is markedly better now. I actually left him home 2 days without his hood and without supervision. He did not create havoc anywhere on his body or paws! He still bites some but is very interruptible, whereas before he would not stop- frantically biting feet, flanks,back, belly etc. I realize this is still early but this is the best he has been in years. I can only hope it continues and remains effective with future injections. No side effects so far. Just wanted to let you know since. I do believe he has gained some weight since the start of the Cyptopoint, probably about 4lbs at the most.. as I noticed his weight gain I have cut his food back a bit and he has taken about a pound off. He is now at 84.7lbs. I would like to get him back to 83lbs or so. I have not noticed a marked personality change, other than he is probably more playful at times- hard to be playful in an elizabethan collar, and feeling itchy all the time! We have now had 4 injections, one was 4 weeks after the first, the next was out to 8-9 weeks due to some scheduling errors.. and we just got another on last Monday. The one we went too long on didn't seem quite as effective, so I was worried that the effect was diminishing. So far the one he just got last Monday at the 4 week mark seems to be better. This last month he also popped up with some dry scabby circular lesions unlike I have seen before, under his armpit and in his groin, and he has been licking his anus more again. Topical treatment has resolved that and he has been better since Monday's injection. We live in CT and the grass allergy levels have been up lately perhaps causing that. I am watching too, to see if the injections become less effective in time! As an aside, we have found that the vet needs to inject his allotted amount split into 2 places, or he finds it very painful..splitting it into 2 seems to have resolved that. Even when he gets more itchy and starts on his paws, or flanks, or scratching on the Cytopoint he is interruptible whereas before, you literally had to move his head to get him to stop biting. There have been a occasional times since his injections, where he has irritated his paws by licking, and so I use NeoPredef/Tetracaine after cleaning the area, and then put his e-collar on to keep him away from it for several hours. Previously he would get his paws or flank raw all the time if he did not have his e-collar on. He literally lived in his e-collar prior to this.. I am also bathing him (only monthly, not as often as I would like) with DermAllay shampoo with ceramides, which seems to help a bit..
As far as seasonal, he has been itchy on some level most of the time.. from puppyhood, and it has simply increased with age. He actually at times is worse in winter, in spite of a humidifier and trying all sorts of humectants or baths for his skin..we have airconditioning with an air filter, and during summer, if he's not outside a whole lot and is inside with the AC he seems better. A boring life though..So far I'd say I'm really pleased with his response.. it is the first thing that has had a beneficial effect on his itching, ever! Obviously it doesn't stop the allergic reactions, which he still has but at least his itching is suppressed to the point he doesn't make a complete mess of himself !
J.P., Connecticut
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8/4/17
Hi Ron!
Sonia began receiving Cytopoint instead of Apoquel. Her general itching overall subsided but she is still rubbing her chin on the stairs( did that on Apoquel too) - not obsessively, occasionally, less than before but over-all it subsided. A couple of growths disappeared, one between her eyes. Other growths seem to have diminish in size. Her lymphocyte count came down to normal but her white blood cell count went up to 24,000. She developed a cough and her nasal keratonosis got worse. Her left eye appeared inflamed. My Vet put her on Baytril for 10 days which cleared up the nose and eye. Cough is still there, slightly better, I'm giving her teaspoons of raw honey to try to sooth the cough. Her activity level got better and higher, she is at least 12 maybe 13 years old and though she's still a chow hound I believe not as bad as before. Her mood seems better and more alert. Before she acted like she was always starving, now its just regular am/pm meals and some treats. Her weight remained the same on her first and second injection of cytopoint. I would say Cytopoint is just as good at controlling the itch. The first injection I managed to extend her to seven weeks giving her claritin one day I felt her itching was rising. We are into the third week of her second injection. Yes I still give other medications.
Sonia had one spot on her chest before we switched from Apoquel to Cytopoint that I was concerned about, that spot spread to different areas of the chest and to her back. It starts out like chicken pox, erupts and develops itchy crusts and spread. If I don't touch them, she doesn't itch. If you touch the eruptions, she is itchy. I have bathed her about every week in a shampoo that my previous Derm Vet invented which has Sodium Hypochlorite in it which she says is basically bleach besides some cerinamides and vitamin E. I scrub the crusty itchy spots and let the shampoo soak for 5-10 minutes. The back appears clear now but the chest is still erupting and she still has a cough which concerns me. She is allergic to staph and this looks like that. The last time she had a staph infection that did not clear up she had to be on Doxycycline and Niacinamide for 30 days. She was on Staph Lysate injections for the last four years every two weeks than three than four. She has had staph infections even on the Staph Lysate before. I think she will always need more than just cytopoint, like medicated baths and ear cleaning unless she lives in a bubble. Does she mind the injections? No. Right now she just gets the Cytopoint and medicated baths, ear cleaning and Zymox. I may have to restart staph lysate and she may need antibiotics again for the staph unless her immune system and the baths can kick this soon. I just switched her from Frontline to Nexgard, and she is on Heartgard. We've tried fish oil on and off, but she gets an upset stomach on it.
Let me close by saying I love Sonia and yet if anyone offered me another dog with skin issues I would run in the other direction. I never realized how bad, how much time and work and money this disease was going to take. If the cytopoint continues to work plus the medicated baths and ear cleaning, it's a blessing compared to the Atopica ( constant soupy ear infections while on Atopica) nightmare and then Apoquel which was much better but not perfect.
M.K
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10/12/16
Several months ago we exchanged emails about Apoquel, and you mentioned a new injectable product [CADI]. Well after 30 years I changed vets, actually didn't change my original vet left and started his own practice [] now we are back together again and he has the injectable. The cost is $57.00 per month but he said it may last as long as three months, so it wouldn't necessary be needed monthly. I am now paying $30.00 per month for Apoquel. So as soon as my present prescription runs out, we're going to give it a try. The cost isn't important, his health and the safety of the new drug is paramount.
Thanks, S.K. Cleveland, OH . Sent from my iPad

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9/19/16
Hi Ron,
Moby's update.
[According to the University College, Dublin] CADI is not [yet] available In Ireland.
D.S., Dublin, Ireland

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9/16/16
Dear Ron,
You asked if CADI was on the market yet in Holland. Normally the first to have the product is the University Clinic in Utrecht. I checked with them [recently] and the answer was NO.
Regards, P.H. , Kaag, The Netherlands

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7/15/16
I wanted to share with you my experience with Apoquel and CADI for my very allergic dog [Wally he is 6 years old neutered Labrador retriever]. My vet [recently] referred him to a veterinary dermatologist; one of the few who had a regular supply [of Apoquel at the time]. Apoquel had an immediate effect and the poor guy was comfortable for the first time. The few times we tried to back off Apoquel (25 mg 1 x/day) for a 100 lb dog, we instantly regretted it. He started itching himself raw, shedding, and smelling. After 2.5 years on Apoquel, Wally was diagnosed with stage-3 kidney disease. [] The skin vet recommended taking him off the Apoquel and trying monthly CADI shots from Zoetis. The CADI shot worked amazingly and completely eliminated his itch and lasted for 5-7 weeks at a time. The first time we administered the shot, we noticed a small rash around his muzzle that eventually resolved. The second shot we feel caused a severe breakout around his muzzle and ear infections in both ears. Once the infections cleared, he was very comfortable and began to grow in a beautiful coat – the likes of which we hadn’t seen before. He was really comfortable and happy. We tried a third shot and right away he developed a severe urinary tract infection. I’m not certain if the [drugs] contributed to his kidney disease, but I do know that his quality of life without it would have been very poor. I was optimistic for the CADI shot, which worked also very well, but seemed to come with nuisance infections – though I’m uncertain if it would have been the same in a healthier dog. Between the two, the CADI gave the best relief, but was expensive and the nuisance infections involve the hassle and expense of vet visits and suffering for the pet. It also seemed that each successive dose of CADI resulted in a longer period of being itch-free, so it could be that over time dogs on CADI will need fewer and few shots. I hope this is all useful information for you. Wally had some complex problems and wasn’t the healthiest dog to start with, so who knows if other dogs would have the same experience on Apoquel or CADI.
For all his health problems, he was a wonderful dog, who really loved his people and we enjoyed a really nice 3 years with him, only wishing it was a bit longer. D.H. Ventura, California

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4/20/16
We have a 6-year-old Doberman Pinscher who [was] itching and scratching to the point that her chin and feet [broke] out in puss-filled sores. We tried the different foods: duck, fat dog formula, etc. Nothing worked. We went to a vet who started her on Apoquel and she [] cleared up. We then went to a dermatologist who said that they are now using a shot called Canine MAB Immunotherapeutic [CADI] instead of the Apoquel. She had the shot on April 6, 2016. She also had a shot called Bactrim [trimethoprim+sulfamethoxazole]. On April 7th she had two nosebleeds and we rushed her to the vet. They cleaned her up, said they didn’t know what had caused it and sent her home. That evening she had a huge nosebleed. On April 14th this perfectly spry and alert dog sneezed and dropped spread-eagle on the floor all four legs paralyzed. All the doctors say there is no connection between the drugs and what happened. She went to an emergency vet who wanted almost $9,000 to do an MRI and we would have to agree to surgery before he would run the tests. They did take x-rays and blood work – all was clear. We transported her back to our local vet and she is on a steroid regime. She is able to slightly move her legs but cannot stand. This is April 19th so its been six days since her collapse. She is very alert, eats and drinks well and recognizes us when we visit her. We still have no answers. If [you know of] anyone who has had these issues or knows anything about what has taken place please let us know. We are desperate for some answers. C. H. , Georgia

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4/23/16
My 10 year old lab mix has been suffering [] from canine atopy [] for about half her life. Initially, it was periodically; but now, constant and quite severe. She had been treated with antibiotics and fungal medication when flare-ups occur, but she is steady-state itchy and licks and scratches constantly.
We have not felt comfortable with what the dermatology vet [] has been offering regarding immunosuppressive drugs – and have steadily refused them. We have always treated our dog holistically, with minimal vaccinations and meds, using a variety of supplements and homeopathics, and acupuncture. Nothing has helped [her] – even with 2-3 baths per week, washing her dog bed covers when she gets a bath, vacuuming every other day, putting on child tees t-shirts to keep her from licking the elephant skin on her armpits, short walks during pollen season, etc. [] We are at a crossroads because we cannot continue to let this dog suffer. At our visit to Dr. ***** in December, he recommended the CADI shots – he is part of the study – since the Apoquel was unavailable at that time. I did some research (there isn’t much out there) and decided the immunotherapy shots were too new – the study just started last quarter of 2015. Apoquel was recommended at our last visit to Dr.***** (last week) – the supply is now available, but with a questionable long-term supply outlook. We have not given the dog the Apoquel yet and with the information at your site, are even more wary of the effects on her immune system. We planned to start M**** off on the maintenance dose (~10mg) after discussing the dosing recommended by the dermatologist with my regular vet (~10 mg 2 times per day for 2 weeks, then 10mg/day – M*** is about 50 lbs) and noting your comment that relief is often achieved at lower doses.
Since it seems that the Apoquel can have a broader negative effect on the immune system than the CADI shots (theoretically, I guess) my question is what is your advice about just starting out with the shots vs the Apoquel ? Thanks.

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3/21/16
Just wanted to give you an update. Our dog, W*****, received two more CADI injections since we last communicated. It worked well for him with no noted side effects. His last CADI injection was at end of January. He has not receive another one since then. He has been on allergy drops based on serum allergy testing for almost 6 months and it seems to be helping. We decided to not give another injection and see if the allergy drops are working to ease his symptoms and it seems to be the case. I know you are not a big supporter of allergy testing and allergy shots or drops, but I do think it is worth trying as there are no other ways to reduce the allergic reactions. Thank you. A. W-M. Saint Petersburg, FL

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12/30/15
Hi Dr. Hines,
I just wanted to share my experience with the new Canine Atopic Dermatitis Immunotherapeutic (CADI) injection. Our Derm vet has been using the CADI in 26 of her patients. My dog is a 7-year-old Standard Poodle. It started having issues with itching and skin lesions about one year ago, Issues that have become more frequent. He is also on thyroid supplement for sub-clinical hypothyroidism and has some signs of IBD. Our vet thinks the IBD and allergy are somewhat related. It has mostly environmental allergies and was started on allergy drops in late Sept. We are continuing with the drops twice a day. He was on Apoquel for about 2.5 months and it worked really well. On Dec 3, he received his first injection of CADI. I have to say it works just as well as Apoquel and I hope that since it is more targeted and will have less unwanted side effects compared with Apoquel. The hope is for the allergy drops to help and he won't need the CADI in the near future. But for now, I am very happy with CADI being available as I feel it is effective without any known side effects at this time. We are actually going back today for another injection, a bit early due to upcoming holiday. It is still working well since the first injection- almost 4 weeks. The dog weights 72 lbs and the cost for the injection was $172 (two 40mg vials). His pet insurance covers it.
A.W-M. St. Petersberg, FL

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9/30/15
Stopping Apoquel and moving to a monthly shot called Canine Atopic Dermatitis Immunotherapeutic vaccine because of the supply demand problem of the Apoquel still going on. My dog is new to Apoquel for allergies he has been suffering from for years. He is on the Apoquel for another 30 days and we have been chosen to get the new monthly vaccine. I will try to update you on the shot when it releases. Our dermatologist just finished training for the new shot. No idea of cost yet either. Breed: Great Dane, DOB: Aug 10, 2008, Weight: 124 lbs. He has 18 Environmental allergies, zero food. Worse molds. Apoquel here cost $2.50 per 16 Mg pill, and he takes 4 a day. $300 per month. They suggested that vaccine will be equivalent or slightly less. Although, he stated again it is just an estimate. They have not mentioned taking both. Switching from one to the other. I hope this regime is effective because I have been watching him suffer for too long. He is my best friend. :-) S.B., Virginia