NeuroCare™ - Purina's High MCT (Medium Chain Triglyceride Diet) That Might Help Your Epileptic (or forgetful) Dog
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Pexion® ?


“Everything Old Is New Again” Ecclesiastes 1:9


Its March of 2017 and NestléPurina just introduced a diet that might help in the control of epilepsy in dogs. (ref) If it lives up to their expectations, I am sure that Hills and other makers of specialty pet foods will follow with competitive brands of their own. Although it is not a "ketogenic diet" per se, it is perhaps partially inspired by them. Instead, the diet's possible helpfulness in epilepsy rests on the possibility that one of the constituents of medium chain triglycerides (= decanoic acid , an MCT highest in coconut oil) might decrease the "excitability" of neurons in you dog's brain. (ref1, ref2, ref3)

Compared to NestléPurina's standard One, Chicken & Rice™, their chicken and corn based NeuroCare™ has more protein (29.0% vs 26.0%),  a bit less fat (15.0% vs 16.0%), less carbohydrate (40.37 vs ~49%) , the same crude fiber (3.0%), more zinc (285mg/kg vs 150mg/kg), more vitamin A (15,000iu/kg vs 13,000iu/kg), more vitamin E (500iu/kg vs 250iu/kg) and omega 6 fatty acids (2.06% vs 1.6%). NeuroCare™ has 0.63% omega-3 fatty acids. The amount of omega-3 in their standard chicken & rice diet is not given. As such, NeuroCare™ should meet AAFCO dog food standards for dogs of any age. (Revolt in the kitchen. when I checked NeuroCare™ ingredient percentages on 3/17/16 they gave % figures that had changed by 3/22/17. So go by whatever is written on the bag)

Other than those differences, the primary – and most important - difference in NeuroCare’s formulation is that it’s fat/oil content contains a considerable amount of medium-chain triglyceride vegetable oils (MCT) that replace the lard that is usually added to dog food as a source of fat (often chicken fat). Fish oil replaced the remainder of the lard. It has been known since the 1920s that a high fat, low carbohydrate diet, as well as fasting (ref), often decreases the frequency of epileptic seizures. However, the use of diet intervention to control seizures went out of style when effective anti-seizure pharmaceuticals were discovered.

But the old becomes new again. Today, there is a resurgence in MCT use by physicians - particularly in epileptic children, where ketogenic diets seem to be the most successful. It might also work later in life; but in adult humans, compliance in sticking to the diet is a major issue. (ref1, ref2, ref3

All bodies, furry or not, needs fuel energy. That fuel can be carbohydrates or fats (in emergencies or excess, proteins too). It is thought that ketogenic diets  are effective in preventing seizures because they shift the body’s metabolism from burning food carbohydrates (in the form of glucose) for needed energy to burning the fats (in the form of ketone bodies) in food to produce energy. Since becoming a fashionable and trendy way for chubby folks to loose weight, lot of non-scientific stuff has been lumped into “ketogenic diet” suggestions. Sort of like the words “organic” “holistic” or “eco-friendly” their meaning is no longer clear . I suggest you not try any of those popular suggestions on your epileptic dog. The tried and true human ketogenic diet is defined as having 4 grams of fat to every one gram of protein+carbohydrate. In that proportion, 90% of the pet's energy comes from fat and 10% from the carbohydrate/protein mix. (ref)

Carried too far to the extreme, your pet's body pH level can be lowered to dangerously acidic levels and a situation called ketoacidosis can result.

Medium Chain Triglycerides (MCT)

Medium chain triglycerides are a type of vegetable oil. They are saturated fats; but they are composed shorter chains of atoms than most of the constituent fats found in lard (animal fat). MCT are lower in caloric value, and are eliminated from the body more quickly than longer chain fats. They are though to be non-toxic, at least when they comprise 10 - 15% of the dog’s diet.  (ref)   But the studies I know of were all short term trials in mature dogs.  Purina does not identify the source of the MCT in their NeuroCare™ diet, other than that it is “medium-chain triglyceride vegetable oil” , but MCT are highest in coconut oil and palm kernel oil. MCTs are not only found in vegetable oil. They are also high in cheese, butter, milk and yogurt. Medium chain triglycerides produce more ketone bodies, than common animal fat that is composed mostly of longer chain triglycerides. MCTs are also absorbed more easily than other fats and oils.

I Have An Epileptic Dog, When Might I Want To Try This Diet Or A Similar Ketogenic Diet ?

1) In some dogs, neither phenobarbital nor a medication plan supplemented with potassium bromide or Keppra adequately control seizures. That number has been estimated to be as high as 30%. (ref) Other potential medications, like Pexion, are not currently available in North America. In those refractory dogs, this diet - or diets like it - might be helpful.

2) I would not begin your dog's anti-seizure program (except in the severest or unique situations) using NeuroCare™ or any other diet based on the MCT/Ketogenic theory. If it appeared to be effective without any standard anti-seizure medications, I would look hard at whether the original diagnosis of idiopathic epilepsy was correct. Many transient problems and some progressive problems can masquerade as idiopathic epilepsy.  I would use this diet primarily in an attempt to keep the dose amounts of anti-seizure medications as low as possible during your pet's long-term care. More than half the dogs taking anti-seizure medications experience side effect of one sort or another. So keeping the dosages of those medications as low as possible while still preventing seizures  is always the goal. (ref)

What Results Might I Expect For My Dog ?

In epileptic humans, about 30-40% seem to find some help in ketogenic diets. Because the frequency of seizures vary naturally, and the nature of epilepsy varies from individual to individual, quantifying the improvement in humans or dogs can be difficult.  Improvement, when it occurs in humans, is generally seen in 2-6 weeks. Also in humans, the most common side effects are indigestion, diarrhea or constipation. Studies in dogs are not nearly as common and none of them followed the dogs on MCT diets for more than 3 months. There is only one I am aware of. Hill's Pet Foods ran it in 2005. It did not find a ketogenic diet helpful in epileptic dogs. But it was only a few dogs - too few to base sound conclusions upon. (ref) What Purina is marketing is not a true ketogenic diet. Protein is too high and so are carbohydrates. There is no reason I know of why one would expect a pet's brain to shift its metabolism from glucose to ketone bodies on that diet. But, never-the-less the study, paid for by Purina, found it helpful. (ref

Please remember that only idiopathic epilepsy – the kind where repeated seizures have no physically identifiable cause – responds to ketogenic diets. Idiopathic epilepsy is the underlying cause of seizures in less than half the dogs that have experienced a seizure. (ref1, ref2)

Canine Cognitive Dysfunction (CCD) – Doggy Alzheimer’s Disease

Purina also suggests NeuroCare™ as a way to deal with the decreased mental acuity of old age (=CCD). They printed a handout for veterinarians to distribute to pet owners to help them decide if their pet might be suffering from CCD.  (ref)

You and your pet’s brain can fuel its activity either by burning the glucose in blood or - during fasting and other low blood glucose situations - it can use the ketone bodies produced from dietary and stored fat as an alternative fuel.  In fasting situations the ketone bodies (acetoacetate and β-hydroxybutyrate), produced in the liver, are the fuel that allows the brain to continue to function. (ref)

Neither your doctor nor your veterinarian know what causes senile dementia (Alzheimer's disease). We do not know if chronic inflammation might be one of the causes. Both PUFAs and MCTs are thought by many to decrease inflammation. (ref)

Purina markets NeuroCare™ as being rich in EPA+DHA, Omega-3 fatty acids (PUFAs) as well as MCTs to help support "brain health" and antioxidant Vitamins E & C to support a healthy immune system. Not all research supports that; but some does. (ref) However, in 2016, the prestigious Cochrane Review reviewed all the studies and found no real evidence that omega-3 PUFAs slowed or prevented mental decline. (ref)

[Cochrane's evaluation of the effectiveness of PUFAs in improving refractory epilepsy in humans was not much better. (ref). As far as PUFA's effects on canine epilepsy, in 2009, one Brazilian vet thought that Omega-3 fatty acids (aka ω-3 or Ω-3 PUFAs) helped his great dane patient (ref); but a UK trial in 15 epileptic dogs found PUFAs ineffective. (ref) ]

Purina also make that "brain health" claim - laced with glowing testimonials - for their Pro Plan Bright Mind Adult 7+ dog food, But gives no scientific evidence or data to back that up either. (ref)  Hills did a study adding MCT, fish oil and carnitine - probably in the development of their “Age Defying” Adult 7+ and Adult 11+ line. (ref), but ended up only increasing the carnitine. (Hills markets so many niche formulas that it is hard for me to keep up with all of them and their claims. Perhaps, they have some other a high MCT formulation I am unaware of.)

MCTs helpfulness  in Alzheimer’s - human or canine -  remains quite hypothetical. (ref)   As for the  added Omega-3 fatty acids in NeuroCare™, some human results are positive (ref1, ref2, ref3)  and some are negative (ref1, ref2) In 2010, Purina published a study they had commissioned that concluded that old beagles fed a high MCT diet did better on some mental abilities tests. (ref) The authors implied that the improvement might have been due to a decrease in an old dog's brain ability to utilize blood glucose [Probably true. I was once the veterinarian at the National Institute On Aging and our older beagles appeared to have difficulty utilizing glucose (ref)] and that the ability of MTCs to provide a substitute brain energy source (=ketone bodies) might have resulted in a clearer mind. But they did not design the study to test that theory and make no such claim now for their NeuroCare™ product (at least none I'm aware of).

If your dog's decline in mental abilities were related to certain liver problems, (eg cholestasis) it is conceivable that MCTs might be beneficial since they are absorbed even in the absence of the bile salts normally produced by your dog's liver. Without their normal ability to absorb fats, those pets can also be deficient in the fat-soluble vitamins A,D,E, & K. So any dog food with moderately elevated levels of those vitamins might be helpful.

I cannot tell you if NeuroCare™ or a similar recipe might benefit your forgetful pet. Nobody can. Try it for a few months and see.

Then let me know.

Your Feed Back Is Appreciated

So as far as I can determine, the likely value of feeding NeuroCare™ to your dog is still up in the air. As with all new products and therapies, information gathers over time. Was NeuroCare™ helpful for your epileptic or forgetful dog? Did he/she enjoy eating it? Did its weight go up or down? Were seizures less frequent or less severe? Was it the only change you made to your dog's current therapy? Were you able to lower its dose of phenobarbital, potassium bromide, Keppra, Pexion, etc? If so, by how much? Did the pet’s blood work results change?  What other changes have you noted on this new diet?

How about you elderly pet’s mental abilities, forgetfulness and alertness? Do you feel it slowed the advances of Father Time?  Did its number of potty accidents decrease?  Did it sleep less? Was it more active?

Ultimately, it is pet owners like you – not company infomercials and promotionals or vets like me - that need to give the thumbs up or thumbs down on a product. So Let me know and I will post your emails here and, over time, I'll change this article accordingly.

Some have suggested adding a human-grade coconut oil or an MCT concentrate to your dog’s current, low-carbohydrate, dog food in a similar amount as mentioned in one of my references  (rptref). That could be a commercial dog food or a home cooked product. But if your dog is truly epileptic, its medical and nutritional management need to be in the hands of a qualified veterinarian that you visit - not based on articles like this one that you read somewhere on the internet. Seizures, managed improperly, can be quite violent - even fatal - and some signal other deep and very important health issues. So find a reputable, non-corporate veterinary practice that your friends speak highly of. One that does not intensely market products. Discuss the issue with them. You can point them to this article if you wish. It has the most thorough list of references available on the net.

In an exchange of emails, a leading research physician in dietary methods of epilepsy control in people also noted that the carbohydrate content of NeuroCare™ was quite high if one was attempting to shift brain metabolism from carbohydrates to fats. But he thought the diet perhaps might be useful based on its MCT content alone. I explained to him that it is the carbohydrate that provides the necessary "glue" to bind pet food kibble together during the baking process. And that perhaps that was the reason the diet had so much of it. In "grain-free" pet kibbles, manufacturers simply substitute the carbohydrates from peas, potatoes, soy or tapioca to hold their products together. The fat is sprayed on after baking in an amount limited by the porosity of the kibble. (ref) That physician also experiments with ketogenic diets in epileptic rats. He remarked that the high-fat diet they must use is very messy, the animals get fat all over their fur and that such a diet probably would not be acceptable to a companion animal owner.