Why Is My Dog's Alkaline Phosphatase Level Abnormal ?

Why Is My Cat's Alkaline Phosphatase Level Abnormal ?

To see what normal blood and urine values are for your pet, go here

For an explanation of causes of most abnormal blood and urine tests go here

To see how tests are often grouped, go here

Ron Hines DVM PhD

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Your Pet's Alkaline Phosphatase Level

AP, Alk Phos, ALP, SAP, ALP

Health Problems That Can Cause Too Much Alkaline Phosphatase To Be Present In Your Pet’s Blood :

A mildly elevated level of AP is found in normal dogs and cats when they are immature.

When AP is elevated in mature pets, most causes are associated with a primary or secondary liver problem that prevents the normal flow of bile.

In cats, the two most common causes of elevated alkaline phosphatase are cholangiohepatitis and hepatic lipidosis (HL). In HL, blood bilirubin levels are usually quite high as well. Bile duct obstruction (gallstones) – particularly when GGT enzyme is elevated equally or greater - is sometimes the cause.

Some specialists believe that about 80% of dogs that have a 3-4 fold increase in their AP levels suffer from Cushing’s disease. (ref) Topical, ear and eye medications containing corticosteroids have also been blamed for higher than normal AP levels.

Other possible causes are oral and injectable corticosteroid medications,, FIP in cats, Hyperthyroidism in cats, hypothyroidism in dogs, Less commonly: diabetes, kidney failure-related hyperparathyroidism, liver and bone cancers, liver-toxic dietary toxins (like aflatoxins), widespread granulomas, abscesses, pancreatitis in dogs and cats, upper intestinal inflammation, anti-seizure medications, autoimmune diseases, gallbladder mucocele, occasionally with mammary tumors, healing fractures and an occasional liver reaction to anti-arthritic NSAID-medication. Mild persistent elevations are more of a worry in cats than in dogs.

Alkaline phosphatase levels sometimes go up in dogs with failing hearts and in genetically-based, copper storage diseases of Dobermans, West Highland White and Bedlington terriers, as well in pregnant cats. Hyperthyroidism, as I mentioned before, can also be responsible for moderately increased AP levels your cat. (ref)

Health Problems That Can Cause Too Little Alkaline Phosphatase To Be Present In Your Pet’s Blood :

I know of none; have the test repeated at a central veterinary diagnostic laboratory to confirm results obtained at your local animal hospital. (ref)

Complementary Tests :

Ultrasound exam, liver-specific AP isoemzyme level, ALT, AST, GGT, GLDH, bile acids, Urine cortisol:creatinine ratio, Tests to “zero-in” on the source of the AP (ACTH stimulation test or Low Dose Dexamethasone Suppression Test for Cushing's/Sex-steoid panel, AP isoenzymes, liver or bone or adrenal/corticosteroid), bilirubin (often goes up later in liver disease), Leptospirosis and toxoplasmosis titer, occult heartworm antigen test

The most common cause of a substantially, persistent higher than normal AP reading in dogs is liver disease of one sort or the other; even more so in cats. When GGT rises along with AP, liver disease almost always the cause. A whopping injection of “depo” (methylprednisolone acetate) can keep it elevated for up to six weeks. However, a normal AP reading is not a guarantee that your dog or cat does not have liver problems – it goes up most in the active stages of liver damage but often falls late in the disease.

Drugs associated with liver damage and elevated AP levels include:
Acetaminophen (Tylenol), Amiodarone for heart problems, Asparginase for lymphoma, Azathioprine for autoimmune disease, Carprofen (Rimadyl) for arthritis, Corticosteroids, Griseofulvin for ringworm infections, Halothane anesthetic, Ketoconazole anti-fungal medication, Mebendazole (Flagyl) , Methotrexate anti-tumor medication, Methoyflurane anesthetic, Phenobarbital or primadone given for seizures, sulfonamide antibiotics and tetracycline.

It is not that unusual for a pet that appears healthy to occasionally have moderately higher than normal ALT, bilirubin or Alkaline Phosphatate levels with no apparent explanation. Physicians face the same problem as veterinarians when deciding what to do in those situations. (ref) I generally suggest that the test be repeated in 2 weeks to see if the results are still abnormal. Many times, they have improved. I am also more concerned when a number of liver-related tests are a bit high than when only one is. Of course, if your pet is feeling poorly, has lost weight or the result was quite high, waiting is not a good idea.

.................... DxMe