Why Is My Dog's Urine Protein To Creatinine Ratio (UPC) High ?

Why Is My Cat's Urine Protein To Creatinine Ratio High ?

To see what normal blood and urine values are for your pet, go here

For an explanation of causes of most abnormal blood and urine tests go here

To see how tests are often grouped, go here

Through 2015, this test is best sent off to a central lab and not run in your veterinarian's office. (ref)

Ron Hines DVM PhD

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Your Pet's Urine Protein:Creatinine Ratio

P:Cr, Pro:Creat In Your Pet’s Urine

One of the major problems in judging the amount of protein abnormally leaking into your pet’s urine due to kidney disease is that the amount varies depending on how much your pet drinks. The more it drank before you or your vet obtained the urine specimen, the more dilute the urine will be and the lower the protein content will be in each drop.

Creatinine is also eliminated in your pet's urine. That is normal. (ref) The ratio of those two compounds, protein and creatinine, remains stable in dilute and concentrated urine. So determining the ratio between the protein and the creatinine lets your veterinarian adjust for the "diluteness" or "concentratedness" of the urine sample when judging the significance of spilled protein that the urine sample might contain.

The P:Cr test is not helpful when your pet is dehydrated, when the protein source is somewhere in the kidney structure itself, when the urine contains blood (visible or not), or when the pet has a urinary tract infection. It is alos likely to be inaccurate if the urine contains large amounts of sediment.

Reasons Why Your Pet's P:Cr ratio might be elevated :

All the same reasons for high urine protein content and microalbumin levels

High doses of corticosteroid medications can moderately increase your pet’s protein:creatinine ratio.

.................... DxMe