Why Is My Dog's Trypsin-like Immunoreactivity Test Abnormal ?

Why Is My Cat's Trypsin-like Immunoreactivity Test Abnormal ?

To see what normal blood and urine values are for your pet, go here

For an explanation of causes of most abnormal blood and urine tests go here

To see how tests are often grouped, go here

Ron Hines DVM PhD

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TLI

Your Pet's Trypsin-like Immunoreactivity Results

A somewhat different duplicate version can be found here - sorry about that. .

The TLI test measures the amounts of a digestive enzymes (trypsin and trypsinogen ) in your dog or cat 's blood stream. Those compounds, along with amylase, lipase and chymotryprinogen are formed in your pet’s pancreas and normally find their way into its intestine through the pancreatic duct.


A small amount of these compounds normally slip into your pet’s blood stream. Measuring that amount is a good way to check on the pet's pancreatic function.

Some laboratories believe that the TLI test is the most accurate way to detect dogs and cats whose pancreases are not producing sufficient trypsinogen/trypsin (exocrine pancreatic insufficiency, EPI). Conversely, in dogs that have higher than normal TLI test results, the pet is believed to be experiencing acute pancreatitis.

There are many tests that can help your vet diagnose pancreatic problems and diagnostic laboratories always think that the ones they perform and market are the best. Read about the alternative PLI and cPL® or fPL® (PLI) , lipase, amylase, tests by clicking those links. The reason there are so many is than none of them detect pancreatic problems as reliably as we veterinarians might wish for.

Reasons Why Your Dog’s TLI Levels Could Be High :

High TLI levels are often present in dogs experiencing pancreatitis. However, that is not always the case. Some dogs with Pancreatitis have normal TLI levels. That may be due to the short period of time that the measured enzymes remain present in the blood stream.

TLI levels can also go up in chronic kidney disease and malnutrition.

High TLI levels do not consistently occur in cats that have acute pancreatitis. So for them, the test is only helpful in the chronic pancreatic conditions that limit the amount of trypsin produced (exocrine pancreatic insufficiency or EPI).

Reasons Why Your Dog or Cat Could Have Low TLI Levels :

Both dogs and cats that have chronic pancreatic problems that have affected the amount of digestive enzymes the organ produces (exocrine pancreatic insufficiency or EPI) can be expected to have low TLI levels.

Things like cholangiohepatitis and triad disease in cats are a common causes of EPI. Dogs with pancreatic acinar atrophy (PAA), a type of autoimmune disease, also have low TLI levels. Breeds affected include German Shepherds, collies, and Eurasiers. (ref)

Complementary Tests :

The other pancreatic tests mentioned at the beginning of this article, CBC/WBC and blood chemistry values including blood calcium (mildly low in many cases of acute pancreatitis), urinalysis, review of diet ingredients, abdominal x-rays, ultrasound exam, perhaps pancreatic biopsy

.................... DxMe