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Cytopoint - Dog Owner Comments Page


Ron Hines DVM PhD

Please let us know:

What is your dog's name ?
What breed is your dog ?
Is your dog a male or a female ? Neutered or Intact ?
How old is it ?
Where do you live (just the city) ?
Your initials if you wish ?
How long has your dog been receiving Cytopoint ?
How often does she/he require a Cytopoint Injection ?
Was it on Apoquel before that ? Is it still ?
If it had abnormal blood values on Apoquel, did they improve on Cytopoint ? If you stopped Apoquel, because of skin tumors, did they shrink ?
More infections, less infections or the same # on Cytopoint vs Apoquel ?
What improvements have you noticed in its skin ?
Any changes or side effects other than improvement in the pet's skin ?
Anything else you want other readers to know ?

As you read the letters below, remember that cause and effect are sometimes an illusion. When things occur, one shortly after the other, we call them cause and effect when we believe the first event caused the second event to happen. If we feel that the two incidents were not related, we call the second a mere coincidence. Cause and effect and mere coincidence can be very difficult for us to sort out. It is only when they occur repeatedly in pets receiving Cytopoint that we can be relatively certain that we are not dealing with mere coincidence. RSH



June 3, 2019

We adopted a rescue, [chihuahua] from the Humane Society. Champ Bailey was just 1.3 pounds and about 6 weeks when we got him just before Thanksgiving. They told my daughter not to name him because he probably wouldn’t make it. He had worms, of course, and coccidia but she kept him alive by holding him on her chest with a heating pad and spoon-feeding him chicken baby food. [ ]. The vet noticed a little raw skin on his “elbows.” We began moving him first to fresh pet then homemade chicken & rice. The chewing, itching and raw skin got worse. A skin scrape determined no mites but bacteria and he was started on antibiotics, special shampoo baths, Apoquel & prescription food trials. The itching has calmed a little but the food trials were a disaster. He is now a 6.6 pound mostly Chihuahua but possibly some mix, otherwise healthy guy. [ ]He won’t eat the prescription food and ends up going into hypoglycemic shock. The vet wants us try to Cytopoint but I’m nervous because of our experience with Bella [our previous chihuahua who died subsequent to a Cytopoint injection]. At the same time if we can’t control the itchy skin he will develop other problems. After reading I’ve learned Apoquel is only supposed to be for dogs that are 12+ months so I’m concerned that we shouldn’t be giving him that. Is the Cytopoint worth a try when we aren’t even sure the cause of his itching?

T.J.M. ,  Sent from my iPhone
Has Champ been test-treated for sarcoptic mange, is anyone else in the household itching, has a single flea been found, has a good skin staph antibiotic been used? RSH


May 26, 2019

My dog has IBD (6 year old golden doodle, diagnosed at 4 years old). I gave her Cytopoint to treat black leathery itchy skin on her inner back thighs, and had great results - her skin issue cleared and she was very happy and energetic. Her IBD was non existant - it was a magical ten weeks. Our first injection was good for 5 weeks, the second one also. The third injection did not work - her body stopped responding - her IBD returned (diarrhea) as well as the itchy black skin. 

H. M. , Sent from my iPhone


March 23, 2019

Hi Ron,

My pet is 7 years old mini-schnauzer bitch, called Daisy. She is with me since 3 years. She came almost bald, after being recovered from demodectic mange and mycosis (probably Malassezia). [Daisy is also atopic]] After a quite bad itching last year (actually the whole year) we tried Apoquel first. It helped, but not 100%. And my vet was in doubts about longer application because of potential long-term side effects. We started with Cytopoint on 19th December 2018. Itching disappeared after [a few] hours. It was big deal, because [it was the first time] I was able to heal the destroyed skin parts (all over the dog). No more itching, no extra infections. The first dose lasted about 8 before some itching could be observed. Not so bad as before the injection but we decided to not wait longer and on 19th of February this year she got the next injection, so it's now 32 days. No itching so far. There are still some skin problems, but they can be held under control using appropriate shampoos, Octenisept. After the first injection Staph infections were more frequent but it is still easier to control than it was before Cytopoint.
I can hardly imagine living now without Cytopoint.  [Her] comfort (for Daisy and for me) is incomparably better than before. I have still also some Apoquel (just in case), but have not used since we started Cytopoint.
Best regards

W. J., Rzeczyca, Poland

March 28, 2019 Update on Daisy:

Not many new facts but some rethinking by me and my vet. A few weeks ago Daisy had an external ear inflammation. It looked quite bad but with Octenisept, Sollux and Recicort we came quite fast through this. One week [has gone b now] and we now [have it in] the other ear. Just treating it with Posatex - looks like it [will] heal [just as] fast .Just recalled some weeks ago she had her first an eye conjunctiva inflammation. It [ ] recovered with Vigamox, then the same in the other eye. Before Cytopoint, we had general skin problems, partially [or] on the whole body, but no inflammations like above. Shortly before [beginning] Cytopoint, Daisy had a disaster of the skin of her underbelly including her anus and the surface surrounding it. The difference: before the Cytopoint - the affected skin surface was almost the whole dog. [ ] Now local infections are more frequent, but are easier to heal, because [there is] no itching involved. My vet thinks it may be a kind of side effect. If it continues like that, I would have no doubt [that that is true]. We will stay with Cytopoint as long nothing worse develops. Best, W. J.


February 10, 2019

My dog Wilkie is a neutered, 6 year-old Pug/Shih Tzu mix who was very healthy, aside from many allergies that affect his skin. We live in Lockport, NY. Our vet suggested [a Cytopoint] injection. First he was just lethargic; within a few weeks, he was ravenously hungry/thirsty ALL the time. Gained a LOT of weight.  [ ] I took him to the vet to explore these symptoms. He was diagnosed with hypothyroidism and placed on Thyro-tabs .03 mg, BID. A few weeks later, I noticed he wasn't tracking treats, and seemed reluctant to go on walks, and would walk behind me when he would go. Back to the vet, vision exam, sent to veterinary ophthalmologist...diagnosed with probable SARDS (sudden acute retinal degeneration syndrome). He is now almost totally blind, and on steroids and antibiotics. I am terrified to find out if this is just the beginning and other symptoms will occur. He had ONE Cytopoint injection. I feel responsible for his condition. We are devastated.

J. S., Lockport, New York


January 12, 2019

Dr. Hines,

I would like to tell you our story about our 10-year-old puggle who has been suffering from allergies. [ ] The last vet [  ] placed her on Apoquel.  Within a few weeks she developed a severe bladder infection [  ] Our new vet suggested we put her on cyclosporine. It helped her ear infections but unfortunately it began causing severe bladder infections as the Apoquel did. Our vet then spoke to a friend of his who was a dermatologist who highly suggested Cytopoint. She had her first injection in May of 2018. She received another injection in June of 2018 and again in July of 2018.  At the beginning of August I noticed that it appeared that she seemed to be losing weight. When we brought her in on August 24, 2018 for another injection she had lost 10 lbs. [  ] our vet [  ] ordered a complete SuperChem, CBC.  To our shock, she had a glucose of 597!!!  Full blown diabetes which now she has to receive two insulin injections a day and the diabetes has yet been stabilized.  Two days after Christmas, she went blind from the cataracts.  [ ] All of us have pretty much agreed that we all felt that the Cytopoint injections have been the cause of the diabetes since all her blood work was completely normal until the Cytopoint injections began. 
Perhaps you will not agree with all of this and feel that the Cytopoint drug is safe.  [ ]
Thank you.

A. K.


November 1, 2018

My boy had his first Cytopoint injection 3 weeks ago, and it was like a tiny miracle!   I had used Apoquel for a short time, but the side effects were such that I stopped it.  
I will admit I was very fearful of Cytopoint [ ] Once the Australian summer started, I knew it was more important for him to have a good life right now..  not later.  He still has a little toe nibble now and then, but that is getting less as well.  I put socks on his front feet at night and then he doesn’t bother with his feet.  The fact that it [ ] only targets IL-31 helped me make the decision, but I am still aware that he may develop ADAs, and there may be other issues, such as it may stop working.  For now, I will take whatever I can and this has [positively] changed his life and ours.  His hair is now growing back on his belly and he is so happy and energetic most of the time.  Sometimes he seems a little lethargic, but that could be the summer heat, the antihistamine, or just that he is ageing.  He still has lot of zest for a 12 year old. I thought it was worth trying an antihistamine.  I chose Zyrtec to start with, and with a teeny dose of this, his eyes have stopped watering.  We are lucky his is one of the 20% or so of dogs that respond to antihistamine.  Thank you so much for your incredible information on Cytopoint.  I would not have made the decision to go with it, had I not come to your page.

Kind Regards, R.K. & Muffy , Adelaide, Australia


September 29, 2018

Oscar is my 7-year-old American Bulldog/bull mastiff mix. He is 108 lbs and has suffered from itching and skin infections for years. He’s been on Cytopoint for almost two years. No diagnostic blood work was done previously. I just adopted him 5 weeks ago and had a geriatric profile and urinalysis done. Here are his results: Here are the abnormal values: Total protein 8.3 High, Globulin 5.4 High, ALB/Glob Ratio 0.5 low, ALT 17 Low, MCH 21.8 Low.

C.P. , Sent from my iPhone


September 12, 2018

Cytopoint has completely changed my wirehaired visla’s life. He is a 5-year old neutered male. Within 24 hours of first injection his constant scratching and licking had reduced by 80%. Within 4 days, itching and scratching was gone altogether. The infections and hotspots on his skin healed. They had all been caused by his constant scratching. Red has been on Cytopoint now for 6 months. The summer months in the last few years have been awful for him. He preferred to stay in the house than venture outside and at times looked quite depressed. He has sailed through the summer constantly playing outside intense itching a thing of the past. Apoquel, which he had been on for 3 years, never stopped the constant scratching and gave him little relief. This is a dog that has 48 allergies and would visit the dermatologist every month he had creams lotions tablets washes and Apoquel and I felt we were fighting a loosing battle. Now he gets 1 injection a month with no side effects. His hair has grown back. The only thing he still gets is ear infections. My vet plucks as much hair from them as possible, but his whole ear canal is a mass of hairs. I wouldn’t use anything but Cytopoint now.


July 26, 2018

Every summer my dog gets a shot of Cytopoint because she is allergic to flea saliva.  Every year it worked like a miracle and will last 2-3 months.  Perfect for summer. This year, it did not work at all. The vet is baffled as to its ineffectiveness. (She said she will call me tomorrow with her thoughts). She wanted to give her steroids and other injections. I am a little hesitant.  We can simply avoid the dog park and such areas to keep her comfortable through summer. I wonder if she has grown immunity to Cytopoint although the vet will call me tomorrow with her thoughts.



July 16, 2018

I have a 7-year-old male neutered  Bernese Mountain Dog/Lab cross. He has had skin issues since he was 3. Worst in hot weather. Over the years we have tried a number of treatments for skin infections and itching, including elimination diets, raw food, fish oil supplements, hypoallergenic food, antibiotics, topical creams, medicated shampoos etc. He has had very few steroid based treatments, but a couple of topical creams, ear drops, one short course of pills very early on when his allergies were thought to be a temporary reaction to fleas. He is also hypothyroid and takes meds for that.
He had been on Apoquel for well over a year, and it was working reasonably well, but he seemed to need a higher and higher dose for relief, and would start itching immediately if I tried to lower the dose. As he is over 110lbs at his lowest weight, it was also very expensive.  I read about Cytopoint. My vet said it was worth a try since it was supposed to have fewer side effects. This is also very expensive for us, as he needs 3 vials. He had finished his Apoquel the day before he had the shot. The day after the shot he started drooling, panting, and his skin became very itchy, wet and stinky. His eyes and face puffed up and were itchy and swollen. He was lethargic and would eat - only if hand fed his raw food. He was quite thirsty all the time. The vet put him on antibiotics. My vet is concerned about the Cytopoint's effect on his immune system. We are at the point of considering steroid treatment as a last resort, but will give this a few days to see if he improves. I wonder if the Cytopoint is suppressing his immune system, and slowing down his reaction to the antibiotics.

Thank you.
R.S. , West coast of Canada


May 25, 2018

My Bingo just turned 11. Started suffering with hot spots summer 3 years ago. Had weepy, icky eyes and yeast infected ears for many past years. Stayed on steroids and topical and antibiotics with brief, if any, relief. Got first cytopoint injection end of February, 2018, and today, May 25, received second shot with grooming. It’s been an actual miracle. He stays outdoors with me all day (we made him stay in past two summers for his own comfort, but he is my constant companion and was sad), hasn’t had the slightest itch, NO runny/irritated eyes or ears. Amazing. Although he hadn’t become symptomatic at all, after making sure Vet felt it was safe, we went ahead and re medicated today, full three months after first treatment. I’ve recommended it. Has made a huge, wonderful difference in mine and Bingo’s lives. Really all of our family. Grand kids have played with him since their births.

Thanks. T. M., Central Louisiana.
Sent from my iPhone


May 24, 2018

My 7 yr old Border Collie, Taite, raw fed from 8 weeks to current, suddenly started itching like mad last spring.  She was scratching her elbow area raw and parts of her stomach as well.  I have never had a dog with allergies. Discussed allergy shots with the vet and she got 1 shot of Cytopoint last year. Vet said there have been no side effects to date.  Was sent home with the pamphlet to chart when she stopped itching.  She stopped itching COMPLETELY the very next day. She has not needed another shot at this time, and has not started itching at all yet this year.
I recommended it for a friends dog that was beside itself itching, it took a few days more for that dog to stop, but it finally did too.

Br. M. and The Not So Itchy Taite


March 18, 2018

Here are my Portuguese Water Dog’s experiences with Cytopoint:   
[He is] a large Portuguese Water Dog with a normal weight at 63-66 pounds. [He is] 8 years old. [He has] a history of all-over itchiness to the point that he scratches until his hair comes out. Only itchy from September-May.  He had Cytopoint shots on 3/17, 9/17 and 12/17.  Excellent results - measured by not seeing dog hair all over the house and minimal scratching. The shot seems to last quite some time as indicated above. He still gets a rash on his stomach that needs to be treated with antibiotics. He has gained 8-10 pounds since starting Cytopoint. Currently weighs 76 pounds. His thyroid check revealed normal results. My dog eats a very precisely measured and monitored diet.  We have even reduced the amount of his food with continued weight gain. We can find no reason for his weight gain, except the Cytopoint.  I did note that you have [other] reports of this on your site.  My Vet is contacting his Cytopoint rep to discuss this and hopefully, we may gain some insight.  L. M.
Dear Ms. M.,
Thank you for your email. You are quite blessed that one shot lasts so long ! I hope it continues to do so and I would appreciate you letting me know how he does as time goes by. Regarding his weight gain. I would like to keep up with that too. If he is getting no more calories or less exercise since beginning Cytopoint,  I am unsure how the two could be related. However it is perhaps conceivable. There is a lot of messenger compound “crosstalk” in the body. They “chat” and one often influences the behavior of others.  The messenger compound that Cytopoint targets, Interleukin-31 (IL-31), shares a receptor (docking station) for another compound, Oncostatin M (OSM). OSM can affect weight gain. (ref) Perhaps, in some as yet unknown and complex way, there is a connection. I hope others write to me regarding similar weight changes in their pets.


February 18, 2018

I have a 12-year-old ShihTzu/Maltese. My dog just had his 2nd Cytopoint shot. The first one didn't do much. I'm from the Netherlands. This afternoon I found out that the [suggested Cytopoint] dosage in the U.S. is higher than the dosage in the Netherlands. In the U.S. it's 2mg per kg. body weight. In the Netherlands it's 1 mg. per kg. body weight. I find that rather strange, and that would explain why it's not working very well for my dog. And the costs are way higher here. I'm a bit confused now, should I ask for a higher dosage? And would that be safe.
Thank you.
J.V.S.  The Netherlands
Dear J.V.S. You are correct about that. The European Medical Agency approved their Cytopoint label as recommending a minimum dose of 1 mg/kg body weight while the US FDA approved their minimum dose at 2mg/kg body weight. I believe that that is no more than a clash of bureaucracies. The EMA is considerably more conservative and demanding in their requests for pre-marketing study data than our FDA. If, in one of those studies, they found Cytopoint effective at 1mg/kg, the conservative thing would be to set that as the minimum dose. The EMA does not say that the dose can not be higher.


February 1, 2018

I have a 5 year old boxer who received a second Cytopoint injection yesterday.  (First injection was approximately 6 weeks ago). His reaction immediately was agitation and restlessness. Over 12 hours after injection, he developed vomiting. He ate this AM and seems more “normal” however more needy. Previous to starting Cytopoint, he was taking Apoquel, Zyrtec and 50mg Benadryl daily and did not have as much relief as with Cytopoint. My question is whether the side effects should be considered unsafe for him to continue.
Thank you,
D.M. Omaha, NB

Dear Ms. M.,
That is a very hard question to answer and I am not allowed to comment on individual dogs. Cytopoint focuses on the immune system. The sort of side effects I would expect -if they occurred -would be some type of negative effect on immune cells, not the effects you describe. However, almost all veterinary injectables have contents in their formula in addition to the active ingredient. Many dogs are fearful at veterinary hospitals. That can just be an underlying element in their individual personalities or things like commotion at the facility, scents of another fearful dog (even after its left) or a less than amicable relationship between a veterinarian or technician administering the product. Probably more important, dogs closely key off of their owner's fears and mood. Dogs are exquisitely sensitive to that. So if you were apprehensive, your pet would be too. You cannot hide your emotions from your dog.

Why not call Zoetis Customer Service line and present your concerns to them. Let me know their take on this. Scroll down to items 20-22 on the Zoetis information sheet I have attached. It may have been revised since I downloaded it.
Best wishes, RSH


January 19, 2018

I gave my dog, Gidget, her first Cytopoint Injection in October 2017. On December 18th, 2017, my 3-year-old miniature schnauzer [was diagnosed with [ ] full blown acute lymphosarcoma. [She] is not going to make it. [ ] She had a check up by the vet the day she received her 1st Cytopoint injection in October and had no swollen lymph nodes then. [ ] She was a perfectly healthy three year old dog. She was spayed at 6 months of age, has received the necessary immunizations, along with her annual boosters needed and rabies every three years. She has been on a grain free diet. She lives in a clean environment, frequents community common areas for walks and bathroom use, no pesticides used in the home or exterior of the home, just an overall happy go lucky girl I love so much. She is a spoiled dog who lives indoors but is exercised daily and in the evenings. She had a physical exam by the vet in October. I had mentioned the bottoms of her feet were quite red and she had started licking them. He at first recommended Apoquel, which I declined after asking some questions. He then recommended  Cytopoint and stated no issues, completely safe, many of his patients doing well on it. In December, 2017 my son found a lump under her jaw. He took her in for me while I was out of town and the veterinarian found all lymph nodes were swollen after which they did a biopsy. That day they also gave her another Cytopoint injection because her licking thing had started again. I have attached the Antech pathology report. The vets stated her blood tests were normal. I have started her on CBD (cannabidiol) oil. She is still eating, drinking and still playful at times but the vets do not believe she will survive. (Gidget passed away on 1/22/18)

E.B.,  Dana Point,  California


November 20, 2017
Our vet convinced [us] to switch from Apoquel to Cytopoint due to [its] reduced side effects. [Buster is an English bulldog] We [found] that Apoquel wasn’t as effective over an extended period of time [as it had been] and we were hesitant to increase the dosage, as with any medication, our dog’s health comes first. We discussed the list of benefits as well as side effects - gastrointestinal upset i.e. stomach or diarrhoea. Things have been going well on the Cytopoint  [two injections, a month apart so far] until a few weeks ago when our dog started developing Gastro upset in the mornings. As a young dog he had some G.I. issues and we were prescribed famotidine to deal with acid problems. However those problems subsided and we discontinued the famotidine. For years he has been fine. He is now 9 ½. [] I belong to many Facebook bulldog related groups, and started seeing more people commenting on their bulldogs having gastrointestinal upsets as a result of Cytopoint. We went for his booster injection yesterday and upon reading this in a forum last nigh a light bulb went on that possibly his Gastro upsets were a result of the Cytopoint and not necessarily a result of a previous medical issue from years ago. I was looking into more info when I came across your page and felt compelled to let you know our experience.

G.C.   Delta, BC Canada


October 25, 2017

My dog Grey is an 8-year-old neutered puggle. She was diagnosed with severe atopic dermatitis [skin allergies] when she was 9 month old. Her management over the years included weekly injections of allergy serum and corticosteroid tablets that were required almost every day. In 2014, the steroids were replaced with 16mg of Apoquel once a day. By 2015, the dose of Apoquel had to be doubled to twice a day. In June of 2017, our vet discontinued Apoquel and began Cytopoint  (9mg I believe) every 4 weeks. She remains itch-free for about 2-3 weeks after each injection and has had to resume taking Apoquel for the remainder of the month.
[On Cytopoint, I notice more skin infections versus Apoquel and they are more severe. In September, she developed a severe lower urinary tract infection (UTI). In October, she still had protein in her urine but the number of WBCs in her urine has decreased.]
Don’t know if we will continue the monthly Cytopoint injections now that [almost] daily use of Apoquel is also required.

JMJ, Arlington, VA


August 6, 2017

Hello Dr. Hines,
I have a 9 year old GSD, Dunbar, who has been itchy his whole life and for the last several years he has lived in a hood, since it steadily has increased. He is on Royal Canin Ultamino since he also seem to be an IBD dog although he's never been scoped. I was hoping the diet would also help the itching but it did not have any effect at all. We used Apoquel briefly but it really didn't make more than a slight difference and I was worried about the potential side effects. I have used Omegas, baths, everything I could find that might help. (short of cortisone). He had the Cytopoint injection about 2 weeks ago, and although it took him a full 48 hours to start seeing a difference, he is markedly better now. I actually left him home 2 days without his hood and without supervision. He did not create havoc anywhere on his body or paws! He still bites some but is very interruptible, whereas before he would not stop- frantically biting feet, flanks,back, belly etc. I realize this is still early but this is the best he has been in years. I can only hope it continues and remains effective with future injections. No side effects so far. Just wanted to let you know since. I do believe he has gained some weight since the start of the Cytopoint, probably about 4lbs at the most.. as I noticed his weight gain I have cut his food back a bit and he has taken about a pound off. He is now at 84.7lbs. I would like to get him back to 83lbs or so. I have not noticed a marked personality change, other than he is probably more playful at times- hard to be playful in an elizabethan collar, and feeling itchy all the time! We have now had 4 injections, one was 4 weeks after the first, the next was out to 8-9 weeks due to some scheduling errors.. and we just got another on last Monday. The one we went too long on didn't seem quite as effective, so I was worried that the effect was diminishing. So far the one he just got last Monday at the 4 week mark seems to be better. This last month he also popped up with some dry scabby circular lesions unlike I have seen before, under his armpit and in his groin, and he has been licking his anus more again. Topical treatment has resolved that and he has been better since Monday's injection. We live in CT and the grass allergy levels have been up lately perhaps causing that. I am watching too, to see if the injections become less effective in time! As an aside, we have found that the vet needs to inject his allotted amount split into 2 places, or he finds it very painful..splitting it into 2 seems to have resolved that. Even when he gets more itchy and starts on his paws, or flanks, or scratching on the Cytopoint he is interruptible whereas before, you literally had to move his head to get him to stop biting. There have been a occasional times since his injections, where he has irritated his paws by licking, and so I use NeoPredef/Tetracaine after cleaning the area, and then put his e-collar on to keep him away from it for several hours. Previously he would get his paws or flank raw all the time if he did not have his e-collar on. He literally lived in his e-collar prior to this.. I am also bathing him (only monthly, not as often as I would like) with DermAllay shampoo with ceramides, which seems to help a bit..
As far as seasonal, he has been itchy on some level most of the time.. from puppyhood, and it has simply increased with age. He actually at times is worse in winter, in spite of a humidifier and trying all sorts of humectants or baths for his skin..we have air conditioning with an air filter, and during summer, if he's not outside a whole lot and is inside with the AC he seems better. A boring life though..So far I'd say I'm really pleased with his response.. it is the first thing that has had a beneficial effect on his itching, ever! Obviously it doesn't stop the allergic reactions, which he still has but at least his itching is suppressed to the point he doesn't make a complete mess of himself !
J.P., Connecticut


August 4, 2017

Hi Ron!
Sonia began receiving Cytopoint instead of Apoquel. Her general itching overall subsided but she is still rubbing her chin on the stairs( did that on Apoquel too) - not obsessively, occasionally, less than before but over-all it subsided. A couple of growths disappeared, one between her eyes. Other growths seem to have diminish in size. Her lymphocyte count came down to normal but her white blood cell count went up to 24,000. She developed a cough and her nasal keratonosis got worse. Her left eye appeared inflamed. My Vet put her on Baytril for 10 days which cleared up the nose and eye. Cough is still there, slightly better, I'm giving her teaspoons of raw honey to try to sooth the cough. Her activity level got better and higher, she is at least 12 maybe 13 years old and though she's still a chow hound I believe not as bad as before. Her mood seems better and more alert. Before she acted like she was always starving, now its just regular am/pm meals and some treats. Her weight remained the same on her first and second injection of cytopoint. I would say Cytopoint is just as good at controlling the itch. The first injection I managed to extend her to seven weeks giving her Claritin one day I felt her itching was rising. We are into the third week of her second injection. Yes I still give other medications.
Sonia had one spot on her chest before we switched from Apoquel to Cytopoint that I was concerned about, that spot spread to different areas of the chest and to her back. It starts out like chicken pox, erupts and develops itchy crusts and spread. If I don't touch them, she doesn't itch. If you touch the eruptions, she is itchy. I have bathed her about every week in a shampoo that my previous Derm Vet invented which has Sodium Hypochlorite in it which she says is basically bleach besides some cerinamides and vitamin E. I scrub the crusty itchy spots and let the shampoo soak for 5-10 minutes. The back appears clear now but the chest is still erupting and she still has a cough which concerns me. She is allergic to staph and this looks like that. The last time she had a staph infection that did not clear up she had to be on Doxycycline and Niacinamide for 30 days. She was on Staph Lysate injections for the last four years every two weeks than three than four. She has had staph infections even on the Staph Lysate before. I think she will always need more than just cytopoint, like medicated baths and ear cleaning unless she lives in a bubble. Does she mind the injections? No. Right now she just gets the Cytopoint and medicated baths, ear cleaning and Zymox. I may have to restart staph lysate and she may need antibiotics again for the staph unless her immune system and the baths can kick this soon. I just switched her from Frontline to Nexgard, and she is on Heartgard. We've tried fish oil on and off, but she gets an upset stomach on it.
Let me close by saying I love Sonia and yet if anyone offered me another dog with skin issues I would run in the other direction. I never realized how bad, how much time and work and money this disease was going to take. If the cytopoint continues to work plus the medicated baths and ear cleaning, it's a blessing compared to the Atopica ( constant soupy ear infections while on Atopica) nightmare and then Apoquel which was much better but not perfect.

October 12, 2016
Several months ago we exchanged emails about Apoquel, and you mentioned a new injectable product [CADI]. Well after 30 years I changed vets, actually didn't change my original vet left and started his own practice [] now we are back together again and he has the injectable. The cost is $57.00 per month but he said it may last as long as three months, so it wouldn't necessary be needed monthly. I am now paying $30.00 per month for Apoquel. So as soon as my present prescription runs out, we're going to give it a try. The cost isn't important, his health and the safety of the new drug is paramount.
Thanks, S.K. Cleveland, OH . Sent from my iPad

September 19, 2016
Hi Ron,
Moby's update.
[According to the University College, Dublin] CADI is not [yet] available In Ireland.
D.S., Dublin, Ireland

September 16, 2016
Dear Ron,
You asked if CADI was on the market yet in Holland. Normally the first to have the product is the University Clinic in Utrecht. I checked with them [recently] and the answer was NO.
Regards, P.H. , Kaag, The Netherlands

July 15, 2016
I wanted to share with you my experience with Apoquel and CADI for my very allergic dog [Wally he is 6 years old neutered Labrador retriever]. My vet [recently] referred him to a veterinary dermatologist; one of the few who had a regular supply [of Apoquel at the time]. Apoquel had an immediate effect and the poor guy was comfortable for the first time. The few times we tried to back off Apoquel (25 mg 1 x/day) for a 100 lb dog, we instantly regretted it. He started itching himself raw, shedding, and smelling. After 2.5 years on Apoquel, Wally was diagnosed with stage-3 kidney disease. [] The skin vet recommended taking him off the Apoquel and trying monthly CADI shots from Zoetis. The CADI shot worked amazingly and completely eliminated his itch and lasted for 5-7 weeks at a time. The first time we administered the shot, we noticed a small rash around his muzzle that eventually resolved. The second shot we feel caused a severe breakout around his muzzle and ear infections in both ears. Once the infections cleared, he was very comfortable and began to grow in a beautiful coat – the likes of which we hadn’t seen before. He was really comfortable and happy. We tried a third shot and right away he developed a severe urinary tract infection. I’m not certain if the [drugs] contributed to his kidney disease, but I do know that his quality of life without it would have been very poor. I was optimistic for the CADI shot, which worked also very well, but seemed to come with nuisance infections – though I’m uncertain if it would have been the same in a healthier dog. Between the two, the CADI gave the best relief, but was expensive and the nuisance infections involve the hassle and expense of vet visits and suffering for the pet. It also seemed that each successive dose of CADI resulted in a longer period of being itch-free, so it could be that over time dogs on CADI will need fewer and few shots. I hope this is all useful information for you. Wally had some complex problems and wasn’t the healthiest dog to start with, so who knows if other dogs would have the same experience on Apoquel or CADI.
For all his health problems, he was a wonderful dog, who really loved his people and we enjoyed a really nice 3 years with him, only wishing it was a bit longer. D.H. Ventura, California


April 23, 2016
My 10 year old lab mix has been suffering [] from canine atopy [] for about half her life. Initially, it was periodically; but now, constant and quite severe. She had been treated with antibiotics and fungal medication when flare-ups occur, but she is steady-state itchy and licks and scratches constantly.
We have not felt comfortable with what the dermatology vet [] has been offering regarding immunosuppressive drugs – and have steadily refused them. We have always treated our dog holistically, with minimal vaccinations and meds, using a variety of supplements and homeopathics, and acupuncture. Nothing has helped [her] – even with 2-3 baths per week, washing her dog bed covers when she gets a bath, vacuuming every other day, putting on child tees t-shirts to keep her from licking the elephant skin on her armpits, short walks during pollen season, etc. [] We are at a crossroads because we cannot continue to let this dog suffer. At our visit to Dr. ***** in December, he recommended the CADI shots – he is part of the study – since the Apoquel was unavailable at that time. I did some research (there isn’t much out there) and decided the immunotherapy shots were too new – the study just started last quarter of 2015. Apoquel was recommended at our last visit to Dr.***** (last week) – the supply is now available, but with a questionable long-term supply outlook. We have not given the dog the Apoquel yet and with the information at your site, are even more wary of the effects on her immune system. We planned to start M**** off on the maintenance dose (~10mg) after discussing the dosing recommended by the dermatologist with my regular vet (~10 mg 2 times per day for 2 weeks, then 10mg/day – M*** is about 50 lbs) and noting your comment that relief is often achieved at lower doses.
Since it seems that the Apoquel can have a broader negative effect on the immune system than the CADI shots (theoretically, I guess) my question is what is your advice about just starting out with the shots vs the Apoquel ? Thanks.


April 20, 2016
We have a 6-year-old Doberman Pinscher who [was] itching and scratching to the point that her chin and feet [broke] out in puss-filled sores. We tried the different foods: duck, fat dog formula, etc. Nothing worked. We went to a vet who started her on Apoquel and she [] cleared up. We then went to a dermatologist who said that they are now using a shot called Canine MAB Immunotherapeutic [CADI] instead of the Apoquel. She had the shot on April 6, 2016. She also had a shot called Bactrim [trimethoprim+sulfamethoxazole]. On April 7th she had two nosebleeds and we rushed her to the vet. They cleaned her up, said they didn’t know what had caused it and sent her home. That evening she had a huge nosebleed. On April 14th this perfectly spry and alert dog sneezed and dropped spread-eagle on the floor all four legs paralyzed. All the doctors say there is no connection between the drugs and what happened. She went to an emergency vet who wanted almost $9,000 to do an MRI and we would have to agree to surgery before he would run the tests. They did take x-rays and blood work – all was clear. We transported her back to our local vet and she is on a steroid regime. She is able to slightly move her legs but cannot stand. This is April 19th so its been six days since her collapse. She is very alert, eats and drinks well and recognizes us when we visit her. We still have no answers. If [you know of] anyone who has had these issues or knows anything about what has taken place please let us know. We are desperate for some answers. C. H. , Georgia


March 21, 2016
Just wanted to give you an update. Our dog, W*****, received two more CADI injections since we last communicated. It worked well for him with no noted side effects. His last CADI injection was at end of January. He has not receive another one since then. He has been on allergy drops based on serum allergy testing for almost 6 months and it seems to be helping. We decided to not give another injection and see if the allergy drops are working to ease his symptoms and it seems to be the case. I know you are not a big supporter of allergy testing and allergy shots or drops, but I do think it is worth trying as there are no other ways to reduce the allergic reactions. Thank you. A. W-M. Saint Petersburg, FL

December 30, 2015
Hi Dr. Hines,
I just wanted to share my experience with the new Canine Atopic Dermatitis Immunotherapeutic (CADI) injection. Our Derm vet has been using the CADI in 26 of her patients. My dog is a 7-year-old Standard Poodle. It started having issues with itching and skin lesions about one year ago, Issues that have become more frequent. He is also on thyroid supplement for sub-clinical hypothyroidism and has some signs of IBD. Our vet thinks the IBD and allergy are somewhat related. It has mostly environmental allergies and was started on allergy drops in late Sept. We are continuing with the drops twice a day. He was on Apoquel for about 2.5 months and it worked really well. On Dec 3, he received his first injection of CADI. I have to say it works just as well as Apoquel and I hope that since it is more targeted and will have less unwanted side effects compared with Apoquel. The hope is for the allergy drops to help and he won't need the CADI in the near future. But for now, I am very happy with CADI being available as I feel it is effective without any known side effects at this time. We are actually going back today for another injection, a bit early due to upcoming holiday. It is still working well since the first injection- almost 4 weeks. The dog weights 72 lbs and the cost for the injection was $172 (two 40mg vials). His pet insurance covers it.
A.W-M. St. Petersberg, FL

September 30, 2015
Stopping Apoquel and moving to a monthly shot called Canine Atopic Dermatitis Immunotherapeutic vaccine because of the supply demand problem of the Apoquel still going on. My dog is new to Apoquel for allergies he has been suffering from for years. He is on the Apoquel for another 30 days and we have been chosen to get the new monthly vaccine. I will try to update you on the shot when it releases. Our dermatologist just finished training for the new shot. No idea of cost yet either. Breed: Great Dane, DOB: Aug 10, 2008, Weight: 124 lbs. He has 18 Environmental allergies, zero food. Worse molds. Apoquel here cost $2.50 per 16 Mg pill, and he takes 4 a day. $300 per month. They suggested that vaccine will be equivalent or slightly less. Although, he stated again it is just an estimate. They have not mentioned taking both. Switching from one to the other. I hope this regime is effective because I have been watching him suffer for too long. He is my best friend. :-) S.B., Virginia