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Dear Reader, All advertisements on this site 
are selected by Google, not Dr. Hines
If you have a cat that is + for feline leukemia
or feline AIDS and it received raltegravir 
(Isentress ®) = a human AIDS  medication, 
feline interferon omega, thiamine, 
niacinamide or slippery elm bark in its treatment
plan; I would very much appreciate 
knowing  the results. RSH email

 

 

 

 

 

 

 

 

 

 

Entyce Cat Owner Feedback Page

 

 

Ron Hines DVM PhD

 

I update this article in October of 2018. At that time, Entyce (capromorelin) was not FDA-approved for use in cats. To the best of my knowledge, that is not because the FDA knows something negative about the use of this medication in cats. Aratana Therapeutics (NASDAQ:PETX), the producer of this medicine, is a small, newly-formed company. The company is not expected to post its first profit until 2020. Securing FDA approval for a medication is a very expensive and time-consuming process. A company cannot suggest on its label that their product can be used in a different species unless it furnished the FDA with expensive studies that confirm it works in that species.

Capromorelin’s effects appear similar in humans, rats and dogs, I see no reason, as yet, why this drug might not have worthwhile applications in cats as well as dogs. In fact, the company stated in one presentation that capromorelin's effects on cats were similar. (ref) But cat process certain medications differently than dogs - particularly those that are modified or eliminated by their livers. So I would still be quite cautious in off-label uses in cats until we understand this medication better. The following are some nice people who have written to me about their experiences using Entyce in their cat to stimulate its appetite:

 

 

 

October 3, 2018

I started giving my 10-pound feline leukemia-positive cat, Smudge, 0.2ml of Entyce today in an effort to get her to eat canned food for the extra water it provides. She is takes raltegravir B-1 and B3 vitamins and Feline Interferon Omega to combat the feline leukemia virus. If one didn't know she was FeLV+, one would think she is completely healthy. Smudge is a picky eater; I have tried every canned and dry food that is made. She favors eating dry Purina kitten chow, but even then, it sometimes takes cyproheptadine to get her to eat. Even a small dose of cyproheptadine makes her sleepy and not all there. I hate the way it makes her feel, but she will eat after taking it. Her being, FeLV+, I don't have the luxury to let her not eat until she is starving. That's why I wanted to try the Entyce. The first day I gave her Entyce, within fifteen minutes, she ate one and a half ounces of canned Fancy Feast. However, it was only effective the first day I gave it.

B.B. Jackson, Tennessee

 

July 8, 2018

Summary: My 16 year old cat, Gilbert had a rise in his Creatinine and BUN--kidney issues. He was put on a low phosphorus, low protein, renal diet.  He was eating the new renal diet very well, but suddenly stopped eating, totally, for 3 days. mirtazapine used to work, but did not help, nor many special foods and treats.  Although Entyce, by Aratana, is only approved in dogs, my vet tried it at about 60 percent of the dose recommended for a dog of Gilbert's weight. It worked great, with  soft stool as a side effect. Wrongly thinking more is better, we increased it to the full dosage for a 13 pound dog. His reaction, as only one individual cat, was deep depression, hiding, and one incident of involuntary head shakes.We dropped it back to 60 percent of the dog dose, the side effects, except soft stool immediately went away. He ate well at the lower 60 percent dose.  I  don't know what the long term side effects are of Entyce, but it was urgent and lucky Entyce was available to get Gilbert eating. He gained weight. After two weeks, and we aren't sure of when the need for it stopped, he is eating on his own, doing well, and I have a bottle on hand, in case. It is good 90 days from opening it.
If your cat needs it, I hope that it works as well for you. 

Neal, Nevada USA

June 15, 2018

Gilbert is a 16-year-old cat living in the Las Vegas Nevada area. He sees a feline veterinary specialist. He has as history of elevated blood creatinine, BUN and SDMA (kidney problems) but had eaten well and maintained his normal weight of 13.1 pounds. His blood phosphorus level has remained within normal limits. He is not at all enthusiastic about eating the special kidney diet his veterinarian prescribed for him. On June 1, Gilbert stopped eating. Mertazipine, an appetite stimulant, dispensed by the vet did not help. His weight dropped to 12 lbs. Even his favorite flavor of Fancy Feast did not interest him. Gilbert’s owner succeeded convincing another veterinarian to sell him Entyce:

My vet in Las Vegas does not use Entyce. None of the 10 hospitals I called would provide it either. They didn’t want to use it for a cat but I insisted and gave full permission. The Entyce works. He came home and ate a 3-ounce can of renal diet. He is having some kibble now an hour later. I don’t see any side effect. There is an immediate burst of hunger that rapidly tapers [off].

June 18, 2018

Gilbert is taking 0.3ml of Entyce every morning. It is working. I don’t see side effects. No depression, head movement, etc. He has gained 0.2 lbs since I last wrote. He is up to 13.3 lbs.  

June 19, 2018

Per my conversation with Dr. M, we increased his Entyce from 0.3ml up to 0.5ml. He ate renal food when we got home. At 0.3ml he wont eat renal food. He wants Fancy Feast at 0.3ml. I need a blood type test to consult with U of Penn. They need type A. I am testing this and creatinine and BUN. [the owner is considering a kidney transplant for Gilbert]

June 20, 2018

His Creatinine has dropped from 2.7 on June 8, down to 1.9, now. 1.9 is close to the 1.7 it was back in November before his decline. Every third day he still gets 2 mg of mirtazapine. He still drinks a lot of water and urinates a lot
His differential blood count numbers have gone from low to normal in two weeks.

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February 2, 2018

We have a Main Coon cat, Bailey. We were given Entyce by our vet friend who had samples for dogs. She's an older cat who was diagnosed with fatty liver [disease] and, as a result, had completely lost her appetite. She was hospitalized for over a week with IVs and then we finally decided to start giving her Entice when we brought her home to help her continue eating on her own.
The medication has definitely help increase her appetite. She has more desire to eat and is eating more on her own - although not quite as much as we would like. She has started displaying some weird behaviors with head shaking and loss of coordination while walking, but we are looking into maybe a possible ear infection or other explanation. We have reduced her dosage starting last night, in case it was causing the side effects, but I notice she hasn't eaten as much today already.
We are hoping to be able to keep her on Entyce long enough so that she will not need it [anymore] and will be eating on her own, once her fatty liver condition has improved. I decided to email you since you said you would like information a pet owners using this on their animals, so let me know if you have any questions.

M. M., San Luis Obispo County, CA   Sent from my iPhone

February 13, 2018 update:

Bailey developed some head shaking and tipsiness that our vet thinks is related to an ear infection. So we discontinued Entyce for now. But I definitely feel that the medicine was a lifesaver for her. She was down to 4 lbs and would likely not be here without the medicine.

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