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Entyce® Dog Owner Feedback Page

 

 

Ron Hines DVM PhD

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August 6, 2019

Hi!  Entyce has been a blessing!
My dog stopped eating 7 months after a round of chemo for lymphoma. It’s most likely his lymphoma is back or he has another type of cancer in his liver; however, he’s not only eating well but he acts like he feels so much better! The only thing else we’re giving is prednisone. The effects of the Entyce dose last about 2-3 days before we give him another dose. Not sure how or why Entyce is helping him as much as it is, but for at least the last 3 months, it’s been a blessing !!
Thank you !

L.C., Sent from my iPhone

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May 14, 2019

My 10 month old, 53lb bloodhound puppy has NEVER eaten well. Let to his own devices he would eat maybe 1/2c food EOD maybe. I mix in rotisserie chicken, pork roast, canned food. Doesn’t matter. Just looks at the bowl and walks away. We’ve done tons of [blood work] and it comes back normal (chem, CBC, cortisol levels). I don’t know what else to check. 
So, desperate, I tried Entyce at 3mg/ml. Within an hour he went to sleep for 3 hours mid day. When he finally woke up he was rubbing his eyes (not normal for him). I noticed that his inner eyelids were raised half way up his eyeball and his lower lids were hanging very droopy (not normal for this dog; normally has tight eyes.) Weird. He was following my husband around when he grabbed a snack (not normal for him).  I offered him his food and he polished off 2c very fast (normally eats kibble by kibble and takes forever). He would have eaten more, but I didn’t want to cause any GI issues. But he was asking for more. Seems quite tired. The weird reaction was the inner eyelids covering half his eyes and droopy lower lids.

Bev, San Diego

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April 28, 2019

I read your article on Entyce and I wanted to give you some feedback (and wonder what you’ve learned since you first wrote about it.). We have a 9 y.o.  Bernese Mountain Dog, who was just dx’d with a tumor in her lung - we are awaiting a referral to another center as our country vet, while wonderful, doesn’t have a great X-ray machine. We’re praying it’s a granuloma, but the vet thinks it’s cancer. (She had an infection prior and this started the weird eating pattern.) 
Our girl started to lose interest in food and got down to 65 lbs. They suggested Entyce. It’s a weird product, I have to say. It takes a good 3 hours to take effect and she seems a little “out of it" for a solid 1-2 hours after taking it (like not coming in from the rain…and one night she stayed out in the dark, didn’t bark to come in as usual and was totally freaked out when we came and got her in —  and she just seems off for awhile.) Once her appetite gets stimulated, she eats almost anything we give her and is her old self. She is also panting a lot more than normal as well as drooling, as your article suggests. That lasts for about 8 hours or more. 
I’m wondering if you’ve found any further side effects or have any concerns about a dog dx’d with cancer…

I appreciate your time.
Thanks, T.G.

Dear Ms. G.,

I do not have any specific information regarding psychological changes in dogs that might be related to their receiving Entyce. Because its effects on appetite rely on its similarity to Ghrelin, one might expect Entyce's side effect to be similar as well. But there is nothing about that that has been published. Capromorelin (Entyce) is also a growth hormone secretagogue, that is, it shares some of the characteristics of growth hormone. It is suggested that humans with cancer not receive growth hormone because there are some indications that it stimulates tumor growth. How that might apply to your dog I cannot say. 

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March 13, 2019

My dog hates Entyce. My puppy has been diagnosed with IBD and does not want to eat any brand of hydrolyzed dog food. I have to increase his appetite with Entyce. It is apparently very foul tasting because after it’s administered he shakes his head several times like it’s very bitter and sneezes. The last dose mostly ended up on me and he nearly bit me. Do you have any suggestions for improving the taste?

Thank you,
D. B.

Thanks for the email. Entyce is vanilla flavored. What worries me most is that your dog snapped at you. I do not want you or anyone in your family to get bitten. Discuss what happened with your local veterinarian or one of his/her technicians. I do not know that there would be any problem adding a little bit of a flavor that you already know your dog likes; but that would be a decision that would have to be made by your local veterinarian, not me. Aratana customer service might offer you advice on that as well.

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March 7, 2019

My 14 yr old GSP, Ellie, developed severe anxiety.  She constantly shivered and shook and wouldn't eat. Never leaving my side and couldn't stay close enough.  I took her to the vet and she had lost 8 lbs from her previous 62 lbs 8 months earlier.  The vet prescribed Entyce.  The prescribed amount gave her massive diarrhea but she was eating.  So eventually I figured out that 1/3 of the prescribed dose was all she needed.  She's such a sweet old lady and so loving.  It's heartbreaking to witness her deteriorating.   I'm thankful for the product.

D.K.

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January  31, 2019

My foster dog, Russet Spuds, was diagnosed [ ] with a [cancerous mass close to one of her heart valves].  She lost 5# in 2 months and was skin and bones, no energy and not eating.  I started her [on] an all natural diet.  She also was put on prednisone and Entyce.  I can’t tell you which one of the three changes (food, pred or Entyce) helped pull her out of her near-death experience, but she is still alive and has gained back all 5#.  Of course the cancer has changed her taste buds so I am constantly changing what she is eating (what she eats in the morning is not necessarily what she will eat at night or for a snack).  She goes through periods of not wanting to eat and I put her back on the Entyce that does seem to help.  [ ]  After she starts eating on her own, then I stop the Entyce.  In the past several days, she has had no appetite and I have given her Entyce in the evenings.  I did not read your article until tonight and did not realize that Entyce would work within an hour or two.  I experienced that tonight.  I fed her fresh air fried hamburger for supper that she would not eat.  Then I gave her Entyce and an hour later I offered her the warm hamburger again that she would not eat so I made it into a slurry. She drank all of her supper that way.  When she goes through periods of not eating, its the Entyce and slurry that help her through it.  She is happy, tail wags, looks perfectly normal so I know its not time for her to cross the bridge and I am grateful that I have something that will help her.

Russet’s Foster Mom!

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December 4, 2018

My dog, Bodhi, was diagnosed with HCC [malignant liver tumor] [and a spleen tumor subsequently]. I opted for a Chinese herbal protocol over chemo. [I am a veterinary technician]. I have kept him eating with Entyce. [ ] I stopped the entyce about a month ago, but am starting [to give it] again. He was on [Entyce] from about May until a month ago. He dislikes the taste and has been doing Ok with the 5mgs of prednisolone  (just started a month ago), and a quarter or less of a 7.5 mg mirtazapine. He is on I'm Yunity and Yunnan Baiyao daily. Another herb was added called Chai Hu Jia Long Gu Mu Li Tang, per the Michigan protocol. I have stopped the last herb combo mentioned as I was concerned it was affecting appetite negatively. I would not have resorted to all these drugs but I will not watch him starve to death and he still eats while on them, enjoys walks each day for a couple hours and has a happy tail. When he is ready to leave I will honor the love we share and do what must be done although I will miss him forever. []

Thank you for your time.

C. M. & Bodhi

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October 21, 2018

Our 14-year-old Standard Poodle has a pituitary tumor and Cushing's disease. [ ].  His tumor is causing neurological symptoms including gait issues and loss of appetite. We have been using Entyce for 10 months. He eats with it, but still very difficult to feed him. However, without the Entyce he will not eat at all.  It has really helped us deal with his anorexia.

Kind regards,

V.G. PhD, RN, Kansas City, MO

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October 9, 2018

I read your article and wanted to let you know that my 15-year-old cocker spaniel, Zeba, was started on Entyce a week ago and it immediately improved her appetite.  She [had] stopped wanting to eat and I was having a lot of difficulty getting her to take her meds.  She has oral melanoma, kidney, pulmonary and heart disease.  She is also blind.  She is looking great and walking around with her tail wagging.  She gets the [Entyce] med at noon every day and her appetite at noon was at forst better than breakfast. Now she is doing great eating at breakfast and dinner.
Sue,  Sent from my Verizon LG Smartphone

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August 4, 2018

Thanks to this miracle medication, Entyce, my 16 1/2 year old flat-coated retriever Sophia is eating again. She was starving herself to death.  No matter what changes of foods or even the lean beef and chicken I cooked for her but she would not eat. Dinner time was a nightmare for her and I. [Now she has] gained around 6 pounds in about a month of taking Entyce. I cannot say enough how grateful I am that this medication was invented.  It has saved my dog's life for as long as God wants me to have her.

E.G.,  Wesley Chapel, Florida , Sent from my iPhone

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June 28, 1018

My 17 year old miniature poodle, Porkchop, stopped eating a couple of months ago and lost substantial weight. His lab work is generally very good but he has had some IG issues, he is blind, has severe arthritis in his spine, collapsing bronchi and a small nodule in one lung. He sees an internist regularly and overall, was doing okay until he lost his appetite and dropped a couple of pounds. Pork Chop looked very frail and had little energy. He is on a very small daily dose of metronidazole for some colitis issues and we had been administering mirtazapine for quite some time.  It had reached the point where the last option was to send a IG study to Texas A&M. Pork Chop looked so frail I had actually made some prearrangement at the pet crematory as his quality of life was rapidly deteriorating. I read about Entyce on line and asked the internist if we might try it. At that point we really had nothing to lose and although he hadn't used it much, had some in stock. It took a couple of days but I noticed an improvement in Pork Chop's appetite. I was cooking all sorts of special things for him to help encourage him to eat and gradually his appetite did pick up. Within a month or so he had regained his lost weight, was back to eating normal dog food and no longer looked frail. He has more energy and is much more like himself. This past week I discontinued Entyce and his appetite has continued to be very good.
Again, thank you for the invaluable service and all the information you provide to us pet owners!
Best Regards, C.L.   Sent from my iPad

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January 28, 2018

Hi,

My dog Aime will be 12 in March. She has lost a lot of weight and had been refusing food for some time. She went to the hospital and they really didn’t find anything remarkable. [I am ] giving [her] Entyce. She’s doing great. Eating much better, gained weight though not a tremendous amount. I have not observed any side effects whatsoever. She’ll be going for a follow up again the second week of Feb. and we’ll see what she weighs then. I can still see all her ribs but her attitude is good for a senior girl.

K.R.,  N. W. New Jersey

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December 13, 2017

Hi there,

I have an elderly male mini schnauzer who has always been a voracious eater but in the last year or so he has become less so. Throughout his life he has eaten Solid Gold dry food but I have now tried about everything: ten different kinds of canned food, “Fresh Pet,” and recently I have been cooking chicken and rice for him. In the last ten days or so his refusing food has become [] alarming.  Some days he doesn’t eat at all.
He also suffers from heart disease, for which he takes benazepril and Pimobendan and [he has] dementia. I read up on the drugs he takes and called my vet to ask if they could be contributing to his loss of appetite (though the start of the decline predated the drugs). I am also aware that dementia comes with changes in eating habits.  I was thinking that dropping the drugs to see if he regained his appetite might be worthwhile; there’s not much point in forestalling heart failure if he starves himself to death.  My vet agreed with this strategy but when I asked if she had any other ideas she said she had just been reading about Entyce but that she hadn’t tried it yet. I picked some up and gave it to him at about 4:30, by 7:00 he was eating everything in sight.  I have kept (small) bowls filled with several different options for him in hopes something would “entice” (see what I did there?) him.  He had eaten two bowls and was on the third !  I actually took it away for a while so he wouldn’t just make himself sick with too much all of a sudden.
Anyway, I couldn’t imagine that it could work that quickly …so I went to the web and found your article.  A few hours, huh?  That is my experience and I am thrilled !  I will be very interested to see if it also helps with some of his dementia symptoms but even if it just ensures that he eats it’s a big improvement.
Thanks for filling in some of the gaps for me it was helpful to know more about the drug.  I will be doing regular bloodwork to watch for any of the side effects you noted.

J.I., Jacksonville, Florida

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December 1, 2017

I have been using Entyce with my 17 YEAR old dog, Jones, for the last week. He developed chronic gastritis last year and had lost his desire to eat. I give Entyce at 2:30pm and by 3:30 he is hungry. He continues to show appetite for up to 8 hours later but by morning is no longer interested in eating. I am considering moving up the time when I administer Entyce. Since he is on a very limited diet due to the gastritis and food and fat reactivity, the food itself held no interest to him. Before Entyce he would spit out his food if I tried to feed him. Now he gobbles his food and asks for more. It will definitely extend his life. He is an extremely active old dog and now he can eat. It is wonderful to see him interested in food again.

M@aol.com , Northeastern Ohio