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Dog Owner's Galliprant Experiences

12/9/2017

Hello Dr Hines,
I read your article on Galliprant with much interest because my dog has been taking it for off and on for several months and I have been unsure as to whether I should continue it. This is our story:
My dog Sydney is an 11 yr old mix breed (cattle dog, hound, Shepherd), neutered female. []She’s had hip arthritis for several years. She was on meloxicam intermittently and then continuously (every other day) for a couple years when we discovered she had a very high creatinine (2.7) that returned to normal (1.4-1.5) [when discontinued]. Although it was never proven to be caused by meloxicam[]. After taking part in a drug study for arthritis at NCSU early this year [chew containing fish oil supplement] – may have been placebo and didn’t do anything for her), the Vets gave her a 30-day supply of Galliprant. It was unclear if it was working so I did not continue it. But then started giving it to her again in late summer when her hips seemed to flare up. [] It does seem to help to some extent and she’s been taking it every day for a month, in addition to 200mg gabapentin BID (for hip and back pain). Recent (last week) bloodwork shows her creatinine slightly elevated at 1.6. All other labs (liver) were normal. I am debating whether to continue it further because it does appear to help somewhat (not as much as meloxicam) but I worry about her kidneys. 

Many thanks, D., Apex, NC

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10/29/17

Ron,
Your article on this medication was fascinating. Gives me a solid understanding of what am giving my dog.
My 10yr old, 42 lb , neutered male G. Shepard/ridgeback, Scout, started taking Galliprant 3 weeks ago, I think the medication has been very effective. He hasn’t taken any previous medication for his arthritis. Prior to taking the meds. he didn’t want to jump into the car or on beds. Sometimes he would just flop down in the driveway and refuse to get in the car. Frankly, within 10hrs. I noticed an improvement in his mobility and attitude. Three weeks out he doesn’t hesitate to jump up onto things and he is playing with other dogs with enthusiasm. Pretty impressive results. Today I did notice some of the side effects you mentioned. His bowels were loose and mucous was present and there was a greenish cast to them. It isn’t clear to me if the
side effects can be expected to abate or not, He hasn’t had any blood work nor use an activity monitor.
Thanks for the informative piece.
A.L. Sacramento, CA

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9/7/17
Galliprant has made a huge difference in my (westie) Gracie,  
Gracie will be 9 in December.   She was diagnosed with chronic immune mediated polyarthropathy [autoimmune disease] about 2 years ago. .  Her front legs bowed, especially at the elbows/knees and her toes on the front legs are spread apart.  She was put on tramadol and prednisone, which help a little, and a brace.  Then a friend told me about PT [Physical therapy] for dogs. She's been going to PT weekly for a several of months, receiving PEMF therapy, class iv therapeutic laser in all her legs and water-walking treadmill.  That helped her get some strength back in her legs and improved her motion slightly. Dr **** told me that Galliprant would be available this year   After being off prednisone and tramadol for 2 weeks, she began, using Galliprant. I saw a slight improvement in her movements by the end of the first week.  .  She been on the Galliprant for about 2 months.  She's a new dog!    She still has the problem caused by the disease, but she's back to being more active - like before this problem developed. Gracie has a dog stroller for her to use whenever she needs.  We use it after coming back from PT.   I bring her to the house, it's a long walk, in the stroller and park it beside the bed so she can get out when she is ready. [] Then a couple of weeks ago, she was feeling so good, that she decided to jump out of the stroller to  the floor.  Luckily I still had a leash hooked to her harness and was able to help her down.   Now she's playing with her star, again, before bed, putting her front feet on someone legs.  Most people don't want their dogs jumping up to do that, but I glad she's feeling good enough and the vet office and my friends are happy she can do it again too. Lately she's been scratching.  I sure hope it's not related to the Galliprant.  The antibiotics don't seem to be working, so we will be going for a follow up appointment today. Linda

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9/5/17 her initial email of 8/27/17 below:
Hello, Ron,
Well, I need to revise my report to you.   Here's what happened...
After a couple days without any meds, his limp increased about 90%, so we initiated Gabapentin. Again, no reduction in pain.  It got so bad he would lift his foot when standing in the house, even on non-walk days.  We added 200mg of Tramadol for two days and it was apparent when the Tram would wear off after several hours.  SO.......I put him back on Galliprant, and his pain level is back down 90%....and I'm NOT exaggerating.  I now know clearly how painful that foot is without NSAIDs.  
I have an appt next week at UC Davis with their Integrative Med section, just in case they can recommend any other pain regimen, such as acupuncture.  Plus, they would refer him to Ortho if they think the foot needs reevaluation. Thus, I was simply too cavalier about "save his liver and let him live with the foot pain".  Now that I know how painful that foot is, I'm certainly on board with the perspective that mitigating the foot pain is more important than his liver values. There might be additional alternatives, such as surgery, but right now, at 12.5 YO, his moment-to-moment to comfort is a critical requirement for going forward. G-R. G. ***************************************************************************************************************

8/27/17
Thanks you for your comprehensive article on Galliprant.  You asked for feedback on galliprant use...be careful what you wish for. My 12.5 YO lab has displayed a limp for 10 months, I believe from an injury (his ramp fell off the truck door rim and both the ramp and dog dropped hard.)He was initially diagnosed with a soft tissue injury.  I was told that an X-ray wouldn't be an effective diagnostic tool and that I should try rest.  At the same time, he was being treated over several months for the effects of intubation-induced esophagitis and laryngeal ulcer, was on high doses of tramadol and gabapentin, so his limp was way down on the treatment list. After weaning off the esophagitis meds, and when repeated cycles of rest didn't reduce the leg pain, the diagnosis was changed to arthritis, I was given Rimadyl. Since he's one of the dogs with liver impacts of NSAIDS, we tested him after a couple of months, and his liver values were elevated.  We switched him to Galliprant, and after about a month, the liver values increased further.  In addition, after walks/running after squirrels, and then a couple days of rest, his limp was still noticeable....not serious, but he's been labeled as very stoic by his doctor. Since the he's been receiving glucosamine for 10 years, I recently insisted on an X-ray to confirm the arthritis diagnosis.  The X-ray showed no arthritis in his shoulder or knee, but some arthritis in his foot - two toes and a fractured palmar sesamoid.  I suspect the sesamoid fracture is causing the pain as the onset corresponds with the ramp fall. G-R. G. ***************************************************************************************************************